POS1359 TRANSIENT ELASTOGRAPHY (FIBROSCAN) AS A NON-INVASIVE METHOD FOR DETECTING AMYLOID DEPOSITION IN TRANSPLANTED KIDNEYS IN PATIENTS WITH AA AMYLOIDOSIS

Background Amyloidosis is characterized by accumulation of insoluble fibrils composed different monomers in extracellular spaces organs, and demonstration deposits non-invasive methods important especially for organs difficult to sample. Transient elastography (Fibroscan) a diagnostic method measuring liver stiffness (LS) being used chronic diseases. Objectives We herein aimed search potential fibroscan detecting kidney (KS) associated with amyloid deposition patients AA who received transplants. Methods Renal transplant recipients (RTR) because amyloidosis-related failure (amyloidosis group; AG) RTR due other underlying diseases (control CG) enrolled into this study. KS LS were measured the same physician blinded diagnosis. The results expressed kilopascals (kPa). Local ethics committee approval patient consents obtained. Results Nineteen AG 16 CG included Patient age (p=0.4), gender (p=1), body mass index (BMI) donor type (p=0.2), (p=0.3), frequency rejection history (p=0.4) graft loss (p=0.2) did not show significant difference between two groups. Frequency diabetes mellitus (DM) (p=0.01), median creatinine (p=0.015) proteinuria (p<0.001) higher group than CG. Although was (19.8 [IQR:34] vs 15.8 [IQR:16]), (p=0.5). Baseline clinical laboratory features similar recurrent-amyloidosis (n=6) non-recurrent (n=13). Median score recurrent compared (p< 0.001). However differ groups (p=0.4). In multivariate analysis only renal recurrence (p=0.031; OR=1.18, 95% CI 1.015-1.362). ROC analysis, cut-off value 24.55 kPa provided 83.3% sensitivity 92.3% specificity (LR=10.8, AUC=0.936, p=0.003). both among CG, but significant. Additionally, scores FMF-associated AA, one MEFV variant those variants tended be M694V homozygotes (p=0.027 p=0.08, respectively). There no correlation age, disease duration, duration transplantation, BMI, LS, creatinine, CRP, proteinuria, Table 1. Comparison had amyloidosis Variables Total Recurrence - + p Age (years)* 48 (22) 47 (17) 50 (27) 1 Gender, male Ɨ 13 (68.4) 9 (69.2) 4 (66.7) Duration (months)* 206 (89) 220 (99) 163 (203) 0.08 Diagnosis 28 27.5 (20) transplantation 145 (137) 144 (110) 123 (50) 0.7 Kidney (kPa)* (15.8) 10.9 (7.7) 29.3 (18.9) <0.001 Liver 5.45 (2.8) 5.4 (2.7) 5.9 (8.9) 0.4 Rejection (n, % ) 3 2 (15.4) (16.7) Creatinine (mg/dL)* 1.4 (0.6) (0.7) 1.7 (0.5) 0.24 CRP (mg/L)* 2.7 (4.4) 1.3 (4.1) 3.5 (13.9) 0.3 Proteinuria (33.3) 0.2 (g/day)* (1.2) *median; IQR n, Conclusion groups; however it without disease, which may support using as useful screening establishing recurrence. need further studies able identify yet unidentified amyloidogenic factors. Disclosure Interests None declared